Scientist 3 - Investigative Toxicology

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This position is in the Investigative Toxicology Group within the Department of Translational Safety in Genentech's Research and Early Development organization. The mission of the Investigative Toxicology group is to elucidate mechanisms underlying toxicities observed for our novel therapeutics using hypothesis-driven research to support drug discovery through clinical development. The Investigative Toxicology group provides fit-for-purpose wet lab-based investigation to address target safety assessment, lead optimization and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches. As such, we continuously strive to establish new platforms and technologies to support a dynamic portfolio, novel modalities and emerging therapeutic area needs.

We are looking for a highly motivated individual to fill a Scientist position. This laboratory-based role involves performing, qualifying and implementing biological assays and technologies to support the Investigative Toxicology group, requiring close collaboration with the team and key stakeholders across the organization. Prior experience in an investigative toxicology lab is required, with a focus on the development and optimization of novel in vitro approaches to investigate mechanisms of toxicity using human and animal cells. The ideal candidate should have experience generating high-quality data to facilitate the screening of candidate therapeutics as part of lead identification and optimization efforts. Key responsibilities include culturing and expanding primary cells and cell lines for in vitro screening, conducting assays to assess cytotoxicity and metabolic changes and capturing cell culture images using confocal and high content imaging platforms. Familiarity working with cells derived from various tissue types including but not limited to liver, lung, biliary and ocular systems is essential. Additionally, experience in emerging areas of interest to the Investigative Toxicology group (e.g., immune-driven toxicity, cholestasis / biliary toxicity) is highly desired.

The candidate will play a critical role in developing novel in vitro platforms and methodologies to mitigate potential toxicities of concern for drug discovery programs. This includes designing experiments, making detailed observations, analyzing data and interpreting results. This is an ideal position for a researcher who is enthusiastic about learning and contributing to projects with a broad range of techniques. Strong communication and collaboration skills, a passion for lab-based research and a desire to learn about and integrate multiple aspects of toxicology are essential for success in this role.

The Opportunity:

As an integral member of this dynamic team, you will be:

• Providing scientific and technical support to assays and platforms supported by the Investigative Toxicology group by:

• Performing experiments involving immortalized and primary cell culture, cell viability assessment, ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry. Experience with these methodologies is required.

• Maintaining documentation related to protocol execution and results.

• Writing protocols and contributing to final reports as appropriate.

• Adhering to departmental SOPs to ensure study integrity and quality.

• Conducting experiments with a high level of independence and initiative.

• Performing tasks with minimal direct supervision for routine methods and studies commonly employed by the team.

• Contribution of knowledge and experience in the application of basic theories, principles and techniques of the relevant areas of science, drug and assay development.

• Active participation in lab-wide activities; (e.g., contributes to maintenance of key equipment/process)

• Successfully partnering with others in the lab as needed to accomplish experimental goals and cross-train others when required.

Who You Are:

• Bachelors (BS / BA) and a Masters (MS) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline is required

Technical Experience Requirements:

• 1-3+ years of experience in an Investigative Toxicology lab

• Ability to analyze, integrate and present data in a presentation is required

• Experience with immortalized and / or primary cell culture is required

• Experience with cell viability assessment, ELISAs, gene expression analysis, high content screening, confocal microscopy and flow cytometry is highly desired

• Experience with complex in vitro model systems is highly desired

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $120,700-$224,100 . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.