Senior Research Scientist

Job Summary:

The DeGregori Lab employs genomic, cell culture, molecular biological, and animal modeling methods to better understand how different contexts such as aging or tissue damage alter the evolutionary trajectory of malignant cells. We are seeking a qualified Senior Research Scientist to assist in the broad goals of our laboratory, which are to:

• Develop and employ computational pipelines for the analyses of mutational patterns in normal tissues, with a focus on the blood and lungs.
• To perform other genomic methods, such as genome-wide assays for chromatin accessibility, in order to understand how mutation-driven clonal expansions alter tissue function.
• To develop and employ mouse models of mutation driven clonal expansions in the hematopoietic system, with a focus on understanding how Down syndrome alters these processes.

Key Responsibilities:

• Manage the development of novel analysis methods and software for highly sensitive mutation detection
• Genomic methods including Cut & Run and epigenetic profiling.
• Employ mouse models of mutation driven clonal expansions, which will involve in vitro culture of hematopoietic stem cells, their genetic manipulation, transplantation into recipient mice, and analyses of resulting clonal expansions.
• Prepare results for submission to journals, including writing the manuscript and coordinating with other authors.
• Provide mentorship to more junior members of the lab.

Why Join Us:

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease.

As biochemists and molecular geneticists, we are in the midst of an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell's machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

Why work for the University?

We have AMAZING benefits and offer exceptional amounts of holiday, vacation and sick leave! The University of Colorado offers an excellent benefits package including:

• Medical: Multiple plan options
• Dental: Multiple plan options
• Additional Insurance: Disability, Life, Vision
• Retirement 401(a) Plan: Employer contributes 10% of your gross pay
• Paid Time Off: Accruals over the year
• Vacation Days: 22/year (maximum accrual 352 hours)
• Sick Days: 15/year (unlimited maximum accrual)
• Holiday Days: 10/year
• Tuition Benefit: Employees have access to this benefit on all CU campuses
• ECO Pass: Reduced rate RTD Bus and light rail service

There are many additional perks & programs with the CU Advantage.

Equal Opportunity Statement:

The University of Colorado (CU) is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing nondiscrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply, including protected veterans and individuals with disabilities.

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

• A Ph.D. degree in Molecular Biology, or a related field, from an accredited institution
• Significant experience in scientific writing (>5 years with several first/last author publications from semi-independent work)
• Software development experience (>5 years, including collaborative and independent software development).
• Experience with cell biological methods, including cell culture and flow cytometry.
• Teaching and mentoring experience.

Preferred Qualifications:

• A track record of collaboration and multi-disciplinary research.
• Experience with large databases, such as COSMIC and TCGA.
• Experience with mouse models, particularly for studying cancers and leukemias.
• Significant experience with maintaining large datasets
• Interest and expertise in mutation detection and bioinformatics approaches utilized in the field.

Knowledge, Skills and Abilities:

• Ability to work independently
• Ability to create and present strong research presentations
• Ability to multi-task
• Ability to communicate effectively across a large multidisciplinary team
• Ability to set priorities and schedule work effectively

How to Apply:

For full consideration, please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position

2. Curriculum vitae / Resume

3. Five professional references including name, address, phone number (mobile number if appropriate), and email address

Applications are accepted electronically ONLY at www.cu.edu/cu-careers.

Questions should be directed to: Anthony Davis, Anthony.j.davis@cuanschutz.edu

Screening of Applications Begins:

Screening begins on immediately and continues until May 28, 2025.

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as HIRING RANGE:

$85,000

The above salary range (or hiring range) represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.