Preclinical Modeling Scientist - Center of Excellence for Pediatric Immuno-Oncology

The Center of Excellence for Pediatric Immuno-Oncology (CEPIO) is seeking an experienced Scientist to manage the Center's immuno-oncology preclinical murine modeling core. CEPIO serves as the central hub to advance and coordinate cross-disciplinary studies in immuno-oncology across St. Jude basic and clinical Departments, Cores, and Centers.

The successful candidate is expected to have significant prior experience in developing and standardizing preclinical murine models to support target discovery, validation, and functional testing, including the generation of new genetically engineered mouse models (GEMMs).

The Scientist will play a central role in developing and managing faithful disease models in vivo (e.g., GEMMs, surgically induced murine models) to support immuno-oncology research and translational efforts. This position offers the opportunity to engage in high-impact research with translational potential, contributing directly to developing novel cancer immunotherapies. Maintaining an up-to-date knowledge of, and having a high level of enthusiasm for, new and emerging technologies in preclinical murine modelling for immuno-oncology and their potential applications will be important. This includes beta-testing new tools, customizing technologies to fit CEPIO's research needs, and developing in-house protocols for complex experiments. The ideal candidate will work with collaborators across CEPIO with the goals of establishing faithful models to enable and support immuno-oncology research and translational efforts.

Responsibilities

• Coordinate multiple aspects of research projects and execute laboratory experiments utilizing appropriate laboratory techniques, tools, and methods.

• Provide inputs regarding research protocols and experiments, set up protocols, and assist in developing new laboratory techniques as required.

• Identify, process, organize, summarize, review, and report relevant experimental data.

• Draft sections of research manuscripts as directed.

• Support monitoring and stocking of supplies, and calibration, maintenance, troubleshooting, and purchase of equipment within area.

• Instruct other staff in basic laboratory techniques and procedures.

• Design, troubleshoot, and refine experimental approaches to answer critical research questions.

• Process, organize, and analyze complex datasets, providing detailed reports on findings.

• Provide technical support for ongoing projects, including maintaining datasets, lab documentation, and compliance with safety regulations.

• Engage in collaborative research projects with internal and external teams to advance research and translation in immuno-oncology.

• Maintain regular and predictable attendance, contributing to a positive and productive lab environment.

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required.

Minimum Experience:

• Eight (8) years of relevant work experience is required.

• Six (6) years of relevant work experience is required with a Master's degree.

• Three (3) years of relevant work experience is required with a PhD.

• Prior experience in lab techniques is preferred.

• Experience in lab and scientific project coordination, maintenance, and other research support activities preferred.

• Prior experience with the generation of GEMMs in immunology and/or cancer biology is highly preferred.

Professional Growth Opportunities

• CEPIO provides a vibrant research environment with access to advanced tools and resources, including state-of-the-art imaging platforms and cutting-edge molecular biology techniques. CEPIO fosters a culture of collaboration, offering opportunities for professional development and advancement.

We invite motivated scientists passionate about preclinical murine models and immuno-oncology to apply and join us in pushing the boundaries of immuno-oncology and immunotherapy in the fight against pediatric cancers.

Compensation

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