Research Scientist II

About the Role:

The Research Scientist in RNAi Formulations and Biophysics will be a lab-based position at GNAT Research, focused on hands-on formulation, biophysical characterization, and analytical testing of oligonucleotides for injectable delivery. This role will allow you to be at the forefront of advancing RNA therapeutics and contribute to high-impact projects in the field.

Key Interactions:

• Collaborate with peers in non-viral delivery manufacturing, oligonucleotide chemistry, stability assays, PK, and bioanalysis of oligonucleotides.

Key Responsibilities:

• Formulation & Research: Lead the development of preclinical formulations of conjugated oligonucleotides, applying advanced analytical techniques to support internal and external collaborations.
• Technology Advancements: Identify gaps in technological capabilities and provide recommendations to drive the research agenda.
• Collaboration Management: Oversee multiple external collaborations to ensure timely delivery of project milestones.
• Stability & Storage: Optimize long-term storage and stability conditions for RNAi conjugates and oligonucleotide formulations.
• Analytical Method Development: Develop robust analytical methods and assays for QC and developability assessments of oligonucleotide formulations.
• Communication & Reporting: Communicate research findings to internal teams via presentations and written reports.
• Fast-Paced Environment: Thrive in a multi-disciplinary, high-pressure environment with tight project deadlines.

Qualifications:

• Education:
• PhD with 3+ years of relevant experience (Level II) OR
• Master's with 3+ years of relevant experience (Level I)
• Experience:
• Subject matter expertise in pharmaceutical sciences, oligonucleotide/peptide/antibody characterization, or related scientific fields.
• Hands-on experience with synthesis, characterization, and purification techniques (e.g., NMR, HPLC, Mass Spectrometry, IR, silica gel/reverse-phase chromatography, TLC).
• Extensive experience in the formulation of nucleic acid therapeutics, especially for systemic delivery.
• Analytical method development for solubility, viscosity, degradation, and rheological assessments for complex oligonucleotides.
• Proven experience in project management and collaboration with external CMOs.
• Experience with high-throughput screening methods and design-of-experiment (DoE) for optimizing formulations is a plus.
• Skills:
• Strong verbal and written communication skills.
• Familiarity with automation tools is advantageous.
• Track record of publishing in high-impact journals.
• Ability to stay current with industry trends, advances in RNA delivery, and clinical translation.

Top Three "Must Haves":

1. Lab experience in the formulation of siRNA or oligonucleotides for systemic delivery.
2. Hands-on analytical characterization of oligonucleotides.
3. Project management experience and successful collaboration with external CMOs.

About Advanced Clinical

Advanced Clinical is an award-winning clinical development organization that provides global services including CRO, Functional Support, Quality & Validation, Patient Recruitment and Retention, and Strategic Talent Acquisition solutions for pharmaceutical, biopharmaceutical, biotechnology, and medical device organizations. Our mission is to deliver a truly better clinical experience for our clients and candidates. To learn more about Advanced Clinical which has been named to Chicago Tribune's Top Workplaces, Chicago's Best and Brightest Companies, and Best of Staffing Talent & Client, visit http://www.advancedclinical.com.

Regarding your application

Please know that every completed application is carefully reviewed by the Advanced Clinical recruitment team. We understand the time commitment that is needed to prepare an application, so we respect your effort by thoughtfully reviewing and responding to each application. In return, we ask for your patience as careful review takes time, and we may not be able to respond to every application immediately.

It is Advanced Group's practice not to discriminate against any employee or applicant because of sex, race, color, age, national origin, religion, gender, gender identity/expression, sexual orientation/sexual preference, pregnancy/maternity, genetic information, marital status, physical/mental disability, medical condition, military/veteran status, or any other basis protected by applicable federal, state, or local law. If you have a disability or handicap and would like us to accommodate you in any reasonable way, please inform your recruiter so that we can discuss the appropriate alternatives available.

Job ID # 511044