Postdoctoral Scholar

Position Overview:

We are seeking a highly motivated and skilled Postdoctoral Researcher with expertise in molecular biology, immunology, murine models, and exposure to bioinformatics. The successful candidate will join an interdisciplinary team dedicated to advancing our understanding of immune resistance and differentiation in bladder and prostate cancers in order to develop novel therapeutics. This position offers an exciting opportunity to lead research projects that combine experimental and computational approaches to explore tumor immunology, cancer biology, and therapeutic development.

Recent Lab Publications:

1. Zhang, H., Ly, A., Chou, E., Wang, L., Zhang, P., Prado, K., Gu, Y., Pellegrini, M., Chin, A.I., Role of Forkhead Box P3 in Interferon gamma-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition, Cancer Research Communications, 4 (8), 2024. PMID 39099201

2. Gu, Y., Ly, A., Rodriquez, S., Zhang, H., Kim, J., Zhiyuan, M., Sachdeva, A., Zomorodian, N., Pellegrini, M., Li, G., Liu, S., Drakaki, A., Rettig, M., Chin, A.I., PD-1 blockage plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers. Cell Reports Medicine, 5 (11), 2024.

Key Responsibilities:

* Design and execute molecular and cellular biology experiments, including gene editing, protein analysis, and functional assays

* Conduct immunological experiments to characterize immune responses in murine models of disease

* Perform data analysis and interpretation, integrating bioinformatics techniques to analyze large datasets (e.g., RNA-seq, single-cell sequencing, etc.)

* Collaborate with bioinformaticians to develop and apply computational models that predict immune cell behavior and response to therapeutic interventions

* Contribute to manuscript preparation, grant writing for the lab as well as post-doctoral specific funding, and presentation of research findings at scientific conferences

Qualifications:

* PhD in Biological Sciences

* Expertise in molecular biology techniques, including cloning, PCR, Western blotting, and flow cytometry

* Knowledge of immunological assays (e.g., ELISA, cytotoxicity assays, cytokine profiling)

* Familiarity with CRISPR/Cas9 gene editing and lentiviral transduction in human and murine cell lines

* Proficiency in bioinformatics tools and programming languages (e.g., R, Python) for data analysis and visualization; training is available

* Previous experience working with in vivo murine models (e.g., mouse handling, dosing, and tissue collection)

* Strong analytical and problem-solving skills, with a track record of published research in peer-reviewed journals

* Excellent communication skills and the ability to work both independently and as part of a collaborative team

PhD or equivalent.

* PhD in Biological Sciences

* Expertise in molecular biology techniques, including cloning, PCR, Western blotting, and flow cytometry

* Knowledge of immunological assays (e.g., ELISA, cytotoxicity assays, cytokine profiling)

* Familiarity with CRISPR/Cas9 gene editing and lentiviral transduction in human and murine cell lines

* Proficiency in bioinformatics tools and programming languages (e.g., R, Python) for data analysis and visualization; training is available

* Previous experience working with in vivo murine models (e.g., mouse handling, dosing, and tissue collection)

* Strong analytical and problem-solving skills, with a track record of published research in peer-reviewed journals

* Excellent communication skills and the ability to work both independently and as part of a collaborative team

• 2-3 required (contact information only)

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As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

For the University of California's Affirmative Action Policy, please visit https://www.ucop.edu/academic-personnel-programs/_files/apm/apm-035.pdf.

For the University of California's Anti-Discrimination Policy, please visit https://policy.ucop.edu/doc/1001004/Anti-Discrimination.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct, are currently being investigated for misconduct, left a position during an investigation for alleged misconduct, or have filed an appeal with a previous employer.

• "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, discrimination, dishonesty, or unethical conduct, as defined by the employer.
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  UC Sexual Violence and Sexual Harassment Policy
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  UC Anti-Discrimination Policy for Employees, Students and Third Parties
• APM - 035: Affirmative Action and Nondiscrimination in Employment